Effects of Pre-Procedure Activated Dimethacone on Mucosal Visibility during Oesophagogastroduodenoscopy: A Case-Control Study
Published: July 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/44807.13819
AK Koushik, V Saketh, P Ganesh, S Shanmughanathan
1. Assistant Professor, Department of Medical Gastroenterology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
2. Consultant, Department of Medical Gastroenterology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
3. Professor, Department of Medical Gastroenterology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
4. Professor, Department of Medical Gastroenterology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Correspondence
Dr. AK Koushik,
Assistant Professor, Department of Medical Gastroenterology, SRIHER-DU, Chennai-116, Tamil Nadu, India.
E-mail: drakkoushik@gmail.com
<Introduction: Dimethicone enhances diagnostic accuracy in Oesophagogastroduodenoscopy (EGD). Various regimens have been tried to ease the procedure for better mucosal visibility.
Aim: To evaluate the efficacy of activated dimethicone in improving endoscopic visibility.
Materials and Methods: The present prospective study was carried out from February 2017 to February 2018 in a tertiary teaching hospital, Chennai, India. A total of 2917 patients aged 18-70 years were enrolled for this study. The participants were divided into group S (1540 patients) and group C (1377 patients). Group S received activated dimethicone 30 minutes before the
procedure and group C underwent procedure without any pre- procedure preparation. The mucosal visibility score was evaluated
in both the groups. Statistical analysis was conducted using IBM SPSS statistics (version 23.0). Unpaired student’s t-test and Pearson Chi-Square test are used for statistical analysis of the data and in both, p<0.05 was considered as significant level.
Results: The mucosal visibility score in oesophagus, stomach, antrum and duodenum was significantly better in group S patients compared to group C patients. Duration of endoscopy was significantly (p-value 0.0005) shorter (7.95 min) in the group S compared with the group C (8.17 min). The amount of flush used was on an average 3 mL less for group S than group C, which was also significant (p-value 0.0005).
Conclusion: Activated dimethicone pre-preparation to EGD significantly increased the mucosal visibility during procedure and decreased the endoscopy duration.
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